Latest Research in CAR-T cell therapy research

48 research papers · 2026 median publication year

Top Research Topics in CAR-T cell therapy research

Highest-Cited Papers

  1. A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol
  2. Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia
  3. Structural Foundation of CTLA-4 antibodies: Emerging Platforms for Next-generation Cancer Immunotherapy
  4. Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma
  5. An activation-biased 2B4 costimulatory domain enhances IFN-γ production and supports sustained cytotoxic activity in CD5-targeting CAR-NK92 cells
  6. Antibodies against HLA-E-VL9 enhance NK cell and CD8+ T cell cytotoxicity against tumor cells and HIV-infected CD4+ T cells.
  7. Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth
  8. Baseline IFN-γ-based natural killer cell activity is associated with ex vivo expansion capacity of autologous NK cells in patients with breast cancer
  9. Engineering strategies to address immune and delivery barriers in pancreatic ductal adenocarcinoma: a barrier-matched translational framework
  10. Brief Communication: LSD1 Inhibition Enhances Susceptibility of Primary AML Cells for NK Cell-Mediated Killing
  11. Resistance mechanisms and therapeutic strategies after menin inhibitor failure in acute myeloid leukemia
  12. Tumor-targeted IL-10 synergizes with IL-2 to enhance antitumor immunity while minimizing immune-related adverse events
  13. TCR-T cell therapy for advanced solid tumors: a critical review of the 2026 ASCO annual meeting data
  14. Development and preclinical evaluation of a decoy DLL4-encoding oncolytic HSV-1 for high-grade glioma
  15. TLR8 Stimulation Leads to Microenvironment Activation and Enhanced Antibody-Dependent Cellular Responses in CLL
  16. Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers
  17. Autologous Glypican-3–Targeted, Armored CAR T Cells in Patients with Advanced Solid Tumors: A Phase 1 Dose-Escalation Study of TAK-102
  18. A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer
  19. Key barriers in utilizing advanced T-cell engager strategies on solid tumors
  20. Emerging Biomarkers and Biotherapies for EBV-Associated Cancers
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L3 Region - - 2026 Sep Q3

CAR-T cell therapy research

48 papers

Top Topics (10)

CAR-T cell therapy research15
Immune Cell Function and Interaction10
Virus-based gene therapy research3
Monoclonal and Polyclonal Antibodies Research3
Cancer Immunotherapy and Biomarkers2
Immunotherapy and Immune Responses2
Acute Myeloid Leukemia Research2
Coagulation, Bradykinin, Polyphosphates, and Angioedema1
Neutrophil, Myeloperoxidase and Oxidative Mechanisms1
HER2/EGFR in Cancer Research1

Top Publications (20)

1.A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol2.Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia3.Structural Foundation of CTLA-4 antibodies: Emerging Platforms for Next-generation Cancer Immunotherapy4.Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma5.An activation-biased 2B4 costimulatory domain enhances IFN-γ production and supports sustained cytotoxic activity in CD5-targeting CAR-NK92 cells6.Antibodies against HLA-E-VL9 enhance NK cell and CD8+ T cell cytotoxicity against tumor cells and HIV-infected CD4+ T cells.7.Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth8.Baseline IFN-γ-based natural killer cell activity is associated with ex vivo expansion capacity of autologous NK cells in patients with breast cancer9.Engineering strategies to address immune and delivery barriers in pancreatic ductal adenocarcinoma: a barrier-matched translational framework10.Brief Communication: LSD1 Inhibition Enhances Susceptibility of Primary AML Cells for NK Cell-Mediated Killing11.Resistance mechanisms and therapeutic strategies after menin inhibitor failure in acute myeloid leukemia12.Tumor-targeted IL-10 synergizes with IL-2 to enhance antitumor immunity while minimizing immune-related adverse events13.TCR-T cell therapy for advanced solid tumors: a critical review of the 2026 ASCO annual meeting data14.Development and preclinical evaluation of a decoy DLL4-encoding oncolytic HSV-1 for high-grade glioma15.TLR8 Stimulation Leads to Microenvironment Activation and Enhanced Antibody-Dependent Cellular Responses in CLL16.Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers17.Autologous Glypican-3–Targeted, Armored CAR T Cells in Patients with Advanced Solid Tumors: A Phase 1 Dose-Escalation Study of TAK-10218.A PRK-armed oncolytic adenovirus drives calreticulin exposure for dendritic cell licensing to prime antitumor CD8⁺ T cells and synergizes with anti-PD-1 or CAR-T therapy in colorectal cancer19.Key barriers in utilizing advanced T-cell engager strategies on solid tumors20.Emerging Biomarkers and Biotherapies for EBV-Associated Cancers
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