Latest Research in Synthetic Receptor Engineering

Top Research Topics in Synthetic Receptor Engineering

• CAR-T cell therapy research — 24 papers
• Immune Cell Function and Interaction — 16 papers
• Monoclonal and Polyclonal Antibodies Research — 6 papers
• Acute Myeloid Leukemia Research — 6 papers
• Virus-based gene therapy research — 5 papers
• Viral-associated cancers and disorders — 5 papers
• Cancer Immunotherapy and Biomarkers — 5 papers
• Immunotherapy and Immune Responses — 4 papers
• T-cell and B-cell Immunology — 3 papers
• Immune cells in cancer — 2 papers

Highest-Cited Papers

1. Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance (5 citations)
2. Pericytes within tumour and other angiogenic microenvironments as potential targets for therapeutic viruses
3. Evolutionary rescue model informs strategies for driving cancer cell populations to extinction
4. A first-in-human, phase I/IIa trial of the T cell immunotherapy personalised tumour trained lymphocytes in patients with advanced colorectal cancer: Study protocol
5. Rejuvenating endogenous antitumor immunity via a chimeric receptor-engineered oncolytic virus targeting tumor-associated macrophages
6. Albumin uptake through FcRn promotes tumor-associated macrophage maturation and albumin-bound immunotherapy response
7. Spontaneous lytic reactivation drives a persistent B cell-vector pathway for epithelial dissemination of the Epstein-Barr virus
8. Engineering CAR-NK cell platforms for breast cancer: metastatic interception, perioperative control, and emerging platelet-guided biomimetic strategies
9. KMT9 drives T cell exclusion and dysfunction by promoting PMN-MDSCs infiltration and ARG1 expression in prostate cancer
10. Immune checkpoint knockout screen reveals TIGIT-CD155 interaction as a significant modulator of adapter CAR-T cell function in acute myeloid leukemia
11. Structural Foundation of CTLA-4 antibodies: Emerging Platforms for Next-generation Cancer Immunotherapy
12. Subset-guided IL-15 expansion of NK cells amplifies antigen-specific CD4+ T cell immunity in melanoma
13. An activation-biased 2B4 costimulatory domain enhances IFN-γ production and supports sustained cytotoxic activity in CD5-targeting CAR-NK92 cells
14. A Stiff Achilles’ Heel: How Tumor Mechanics Shape Metastatic Vulnerability
15. Antibodies against HLA-E-VL9 enhance NK cell and CD8+ T cell cytotoxicity against tumor cells and HIV-infected CD4+ T cells.
16. Intratumor delivery of a novel plasmid combination induces high levels of metastatic melanoma regression
17. Boolean-network simplification and rule fitting to unravel chemotherapy resistance in non-small cell lung cancer
18. Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth
19. Baseline IFN-γ-based natural killer cell activity is associated with ex vivo expansion capacity of autologous NK cells in patients with breast cancer
20. The sensitivity of acute myeloid leukemia to CDK8/19 inhibitors is determined by their metabolic profile

Sub-Regions

• CAR-T cell therapy research — 48 papers
• Epigenetics and DNA Methylation — 30 papers
• Viral-associated cancers and disorders — 24 papers
• Immunotherapy and Immune Responses — 16 papers
• Immune Cell Function and Interaction — 14 papers
• Cancer Cells and Metastasis — 12 papers