Latest Research in Bioactive Heterocyclic Scaffold Engineering

Top Research Topics in Bioactive Heterocyclic Scaffold Engineering

• Synthesis and biological activity — 42 papers
• Multicomponent Synthesis of Heterocycles — 16 papers
• Click Chemistry and Applications — 13 papers
• Natural Antidiabetic Agents Studies — 12 papers
• Enzyme function and inhibition — 11 papers
• Carbohydrate Chemistry and Synthesis — 7 papers
• HIV/AIDS drug development and treatment — 5 papers
• Cancer therapeutics and mechanisms — 5 papers
• Synthesis and Reactivity of Heterocycles — 4 papers
• Sulfur-Based Synthesis Techniques — 4 papers

Highest-Cited Papers

1. Synthesis, Structure and Properties of N-Phenyl-2-(thiazol-4-yl)acetamides (1 citations)
2. Microwave-Assisted, Sustainable, and Click-Chemistry Synthetic Approaches to 2-(4-(((Benzo[4,5]oxazolo[2,3-c]triazol-3-yl)thio)-methyl)-1H-1,2,3-triazol-1-yl)-N-(substituted)acetamides and Their Antimicrobial Activity
3. Chromones: Important Templates for Pesticide Development
4. Group-Invariant Certificates and Solvers for Diversity Selection in Combinatorial Libraries
5. Coumarin-triazole hybrids as potent low-toxicity anticancer agents evaluated by in vitro and in vivo 99mTc-MIBI uptake in glioblastoma models
6. Glycopeptide Assembly via Selective Manganese(I)-Catalyzed C–H Alkenylations in Organic Media and in Water
7. Simultaneous Inhibition of PARP-1 and CK2α by Novel Benzothieno[3,2- d ]pyrimidin-4(1 H )-one Derivatives: A Promising Strategy to Combat Homologous Recombination Deficiency-Independent Tumors and Metastasis
8. Integrated AI-Driven Multi-Objective Optimization of Sulfamoylbenzamide-Based HBV Capsid Assembly Modulators: Discovery of 11B-6 with Superior Potency and Drug-like Properties
9. Atom-Economic Synthesis of Indolizine Derivatives via Pyridinium Ylide and Chalcone Using Eosin-Y as a Photo-Redox Catalyst
10. NBS ‐Mediated Mitsunobu Glycosylation: Facile Assembly of N ‐Glycosides from Unprotected Sugars and Application to Polysaccharide Analysis
11. Phthalazine as a medically versatile polyheterocyclic core with underexplored anticancer potential
12. Recent advances in the therapeutic potential of quinoline-piperazine hybrids
13. Design, synthesis, and computational assessment of bis ‑oxadiazole ligands targeting α-amylase and α-glucosidase: DFT, docking, and ADME studies
14. Antimicrobial and Anti-inflammatory Activities of Quinoline Containing 2,5-Disubstituted 1,3,4-Oxadiazoles
15. Discovery of Tetrasubstituted Quinazolin-4(3 H )-ones as Wild-type-sparing, Highly Selective PI3KαH1047R Inhibitors
16. Synthesis, in vitro enzyme inhibitory and antioxidant activities of novel S -Alkylated indole-1,2,4-triazole acyl hydrazones targeting type 2 diabetes
17. Synthesis, characterization and molecular docking studies of novel 6-Imino-2-Methyl-4-substituted- 6H -1,3-Thiazine-5-Carbonitrile derivatives as potential antibacterial agents
18. Novel Sulfur-Containing Heterocycloalkyl Substituted Bicyclic Compounds as Viral DNA Polymerase Inhibitors for Treating Viral Infections, in particular, Herpesvirus Infections
19. Investigations into the Role of the Decalin Ring System on the Activity of Diterpene-Based β-Lactam Adjuvants
20. Synthesis, Biological Evaluation, and Molecular Modeling of Novel Pyrimidine Scaffolds as Prospective Anticancer and Antimicrobial Agents

Sub-Regions

• Synthesis and biological activity — 77 papers
• Natural Antidiabetic Agents Studies — 64 papers
• Multicomponent Synthesis of Heterocycles — 40 papers
• Synthesis of heterocyclic compounds — 33 papers
• Synthesis and Characterization of Heterocyclic Compounds — 33 papers
• Click Chemistry and Applications — 25 papers