A Case of Allergic Fungal Sinusitis-Like Syndrome: Clinical and Immunopathological Comparison With Allergic Bronchopulmonary Aspergillosis

Allergic fungal sinusitis (AFS)-like syndrome refers to clinical presentations resembling AFS that do not fully satisfy established diagnostic criteria. We report a case of AFS-like syndrome in a 33-year-old woman, characterized by the presence of fungal hyphae within eosinophilic mucin despite negative systemic allergy testing, and we evaluate the limitations of current diagnostic frameworks. This report further examines the shared immunopathological spectrum between AFS and allergic bronchopulmonary aspergillosis, highlighting the importance of an integrated clinical approach to fungal hypersensitivity disorders affecting both the upper and lower airways.