The distribution of nano- and microplastics in the human body: a hybrid perfusion-diffusion based PBK model
• Probabilistic PBK model captures polydisperse NMP kinetics. • Transport shifts smoothly from perfusion to diffusion with particle size. • Model predicts organ-specific particle numbers and size distributions. • Mouse-calibrated model scales to human inhalation and ingestion exposure. • Inhalation and ingestion show distinct, feces-dominated kinetic profiles.
Authors
- Nur Hazimah Mohamed Nor (ORCID: https://orcid.org/0000-0002-8086-1833)
- Ira Wardani
- Albert A. Koelmans (ORCID: https://orcid.org/0000-0001-7176-4356)
- Merel Kooi
Institutions
- Wageningen University & Research (NL)
Publication Details
- Journal
- Environment International
- Published
- 2026-06-01
- DOI
- https://doi.org/10.1016/j.envint.2026.110341
- Primary Topic
- Microplastics and Plastic Pollution
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Chemical Industry Council