Acarbose redirects gut microbiome utilization of dietary carbohydrates to suppress anaphylaxis in mice
levels, and reduced reliance on b-type cytochrome-dependent anaerobic respiration. Direct administration of succinate suppressed systemic anaphylaxis and mast cell degranulation in vitro, implicating succinate as a key effector. A human cohort analysis revealed that patients treated with α-glucosidase inhibitors showed a lower incidence of anaphylaxis than untreated individuals. These findings uncover a previously unrecognized gut-microbiota-mediated pathway linking dietary carbohydrate metabolism to systemic immune regulation.
Authors
- Tsuyoshi Miki (ORCID: https://orcid.org/0000-0003-3563-2991)
- Rina Kurokawa (ORCID: https://orcid.org/0000-0002-2238-2826)
- Kyosuke Yakabe
- Masahiro Ando
- Takeshi Haneda (ORCID: https://orcid.org/0000-0002-7506-4530)
- Akiyoshi Hirayama (ORCID: https://orcid.org/0000-0002-0440-6820)
- Yuki Yanagisawa (ORCID: https://orcid.org/0000-0001-6998-6654)
- Yosuke Kurashima (ORCID: https://orcid.org/0000-0001-8588-4033)
- Satoko Hori (ORCID: https://orcid.org/0000-0002-4596-5418)
- Srirat Tanakorn
- Masahiro Ito (ORCID: https://orcid.org/0000-0002-6489-0431)
- Shunnosuke Suwa
- S Fukuda
- Koji Hase
- Shungo Imai
- Haruko Takeyama (ORCID: https://orcid.org/0000-0002-2058-8185)
- Wataru Suda (ORCID: https://orcid.org/0000-0002-2861-9724)
- Yuqing Wu
- Yukinobu Inoue (ORCID: https://orcid.org/0009-0001-8040-5109)
- Yun-Gi Kim (ORCID: https://orcid.org/0000-0003-4251-1848)
Institutions
- International Vaccine Institute (KR)
- University of Tsukuba (JP)
- Waseda University (JP)
- Chiba University (JP)
- Keio University (JP)
- Juntendo University (JP)
- University of California San Diego (US)
- Chiba University Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Fukushima University (JP)
- Kitasato University (JP)
Publication Details
- Journal
- Nature Microbiology
- Published
- 2026-05-12
- DOI
- https://doi.org/10.1038/s41564-026-02350-2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Secom Science and Technology Foundation
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology
- Exploratory Research for Advanced Technology