Acute and Recurrent Rheumatic Fever in the Fergana Valley: A Comprehensive Epidemiological and Clinical Analysis in the Andijan Region

Rheumatic fever remains a critical public health concern in specific socio-demographic zones of Central Asia. Transitioning from the historical term "rheumatism" to "Acute Rheumatic Fever" (ARF) and "Chronic Rheumatic Heart Disease" (CRHD) highlights the direct etiological link to Group A Beta-Hemolytic Streptococcal (GABHS) pharyngeal infections. Evaluating regional variations in the presentation, genetic markers, and clinical progression of this disease is essential for optimizing primary and secondary prevention strategies.