Striatal dopamine availability peaks in adulthood and undergoes age-dependent modulation
Age is a risk factor for several psychiatric disorders. An adolescent peak in striatal dopamine availability is thought to contribute to the neuropsychiatric vulnerability. However, the lifespan trajectory of striatal dopamine release capacity is undefined in most species. Here, we measured lifespan trajectories of striatal dopamine in primates and rodents and identified a delayed developmental peak in adulthood and age-dependent changes in dopamine release regulation by GABA and acetylcholine across species.
Authors
- Marta Andujar (ORCID: https://orcid.org/0009-0007-0265-9967)
- Veronica A. Alvarez (ORCID: https://orcid.org/0000-0003-2611-8675)
- Samantha R. White (ORCID: https://orcid.org/0000-0002-4676-4079)
- Sydney E. Cerveny
- Hannah C Goldbach (ORCID: https://orcid.org/0000-0002-5697-4694)
- Lucy G. Anderson (ORCID: https://orcid.org/0000-0002-8908-2887)
- Alexander C. Cummins
- Reza Azadi (ORCID: https://orcid.org/0000-0001-8649-8046)
- Kenneth A. Pelkey (ORCID: https://orcid.org/0000-0002-9731-1336)
- Bruno B. Averbeck (ORCID: https://orcid.org/0000-0002-3976-8565)
- Chris J. McBain (ORCID: https://orcid.org/0000-0002-5909-0157)
- Evan S. Swanson (ORCID: https://orcid.org/0009-0005-9635-7577)
- Abigail L. Carr
- Peyton Q Harmon
- Racehele Rimondini
- Anna Claire Tangen
- J Hoon Shin
Institutions
- National Institutes of Health (US)
- National Institute on Alcohol Abuse and Alcoholism (US)
- National Institute of Mental Health (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-11-11
- DOI
- https://doi.org/10.64898/2026.11.10.765699
- Primary Topic
- Neurotransmitter Receptor Influence on Behavior
- Type
- preprint