Comparison of Platelet Parameters Between Mindray BC-760 and Sysmex XN-1000 in Thrombocytopenic Patients

This study compares platelet parameters in thrombocytopenic patients using the Mindray BC-760 and Sysmex XN-1000 hematology analyzers. This study was conducted at Dr. Saiful Anwar Hospital from March to June 2023, including 109 thrombocytopenic patients. Platelet parameters, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT), platelet-large cell ratio (P-LCR), and IPF, were measured using both analyzers. The Mindray BC-760 showed significantly higher platelet counts compared to the Sysmex XN-1000, with a mean platelet count of 53,730.908 ± 5,146.488/µL for the Mindray BC-760 and 29,029.336 ± 2,780.506/µL for the Sysmex XN-1000. Similar differences were observed for other parameters, including P-LCR, MPV, PCT and IPF. Passing-Bablok regression analysis revealed small biases for the measured parameters, with proportional bias noted for platelet count and IPF. Spearman correlation analysis showed very strong correlations (r ≥ 0.80) for platelet count, indicating reliable measurements across both analyzers. Strong correlations were found for PCT and IPF, moderate correlations for MPV and P-LCR, and weak correlations for PDW. These findings suggest that measuring platelet parameters using Mindray BC-760 is not different from using Sysmex XN-1000 in thrombocytopenic patients. However, caution is needed when interpreting PDW due to notable differences. That measuring platelet parameters using Mindray BC-760 is not different from using Sysmex XN 1000 in thrombocytopenic patients.