What is the best treatment for primary syphilis?

The evidence strongly supports benzathine penicillin G, administered as a single dose of 2.4 million units intramuscularly, as the best treatment for primary syphilis. Alternatives such as doxycycline are available for those allergic to penicillin, but their efficacy is slightly inferior.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-11
DOI
https://doi.org/10.5281/zenodo.24143484
Primary Topic
Syphilis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

What is the best treatment for primary syphilis?

Tripdatabase
Zenodo (CERN European Organization for Nuclear Research)
Syphilis Diagnosis and Treatment
article

What is the best treatment for primary syphilis?

Tripdatabase
article en

Abstract

The evidence strongly supports benzathine penicillin G, administered as a single dose of 2.4 million units intramuscularly, as the best treatment for primary syphilis. Alternatives such as doxycycline are available for those allergic to penicillin, but their efficacy is slightly inferior.

Zenodo (CERN European Organization for Nuclear Research)
Syphilis Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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What is the best treatment for primary syphilis? — Tripdatabase · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS