Organometallic-Nanoparticle Constructs as CO-Release Theranostics: An Evaluation with Some Group 7 and 8 Metals
Abstract A central issue with the use of transition metal carbonyl complexes in CO-release medical therapy centers around the attendant side effects associated with the products after CO release (iCORMs). In this study, we examined the feasibility of an organometallic-nanoparticle (AuNP@OM) construct as a means to stabilize the iCORM of a photoactivable CO-releasing molecule (photoCORM), as well as for tracking. Four metal carbonyl complexes comprising a group 7 or 8 metal and bearing the 3-di(pyridin-2-yl)benzo[g]quinoxaline (dpb) ligand were assessed, along with their AuNP@OM constructs, for such use.
Authors
- Christophe Sandt (ORCID: https://orcid.org/0000-0002-6432-2004)
- Kien Voon Kong (ORCID: https://orcid.org/0000-0002-5910-6497)
- Zhen Xuan Wong
- Hélène Charlotte Bertrand (ORCID: https://orcid.org/0000-0002-3841-022X)
- Weng Kee Leong (ORCID: https://orcid.org/0000-0003-3198-7111)
- Yongxin Li (ORCID: https://orcid.org/0000-0002-1874-031X)
- Ricky Yu‐Syun Fan (ORCID: https://orcid.org/0009-0008-7333-6994)
- Darryl Heng Yik Ooi
- Teresa Yu Ping Lim
- Benedict Jin Kiat Bay
Institutions
- Agency for Science, Technology and Research (SG)
- Centre National de la Recherche Scientifique (FR)
- National Taiwan University (TW)
- Nanyang Technological University (SG)
- Université Paris Sciences et Lettres (FR)
- Synchrotron soleil (FR)
- École Normale Supérieure - PSL (FR)
- Sorbonne Université (FR)
Publication Details
- Journal
- ACS Applied Bio Materials
- Published
- 2026-11-11
- DOI
- https://doi.org/10.1021/acsabm.6c01529
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00