Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Bladder Cancer Patients Undergoing Radical Cystectomy: A Systematic Review and Meta-Analysis
Poster and supplementary figures presented at the Millin Meeting, Royal College of Surgeons in Ireland, Dublin, 12-13 November 2026. Systematic review and meta-analysis of the neutrophil-to-lymphocyte ratio (NLR) and survival after radical cystectomy for bladder cancer (38 studies, 12,917 patients; PROSPERO CRD420261399528). High versus low NLR was associated with worse overall survival (HR 1.77, 95% CI 1.41-2.22, 15 studies), cancer-specific survival (HR 1.73, 1.20-2.49) and recurrence-free survival (HR 1.61, 1.07-2.42). Each one-unit rise in NLR was associated with worse overall survival (HR 1.08, 1.05-1.10). The supplementary PDF contains the overall-survival forest plot, a summary table of all analyses, the characteristics of each meta-analysed study, the secondary forest plots, sensitivity analyses, the cut-off used by each study and the PRISMA flow diagram. Not peer reviewed.
Authors
- Rowan G. Casey (ORCID: https://orcid.org/0000-0001-6910-0219)
- Peter Lawlor
- Gavin G. Calpin (ORCID: https://orcid.org/0000-0002-0266-2038)
- Cian Hehir
- Zachary Thompson
- Emma Powell
Institutions
- Royal College of Surgeons in Ireland (IE)
- Ollscoil na Gaillimhe – University of Galway (IE)
- Tallaght University Hospital (IE)
- Royal Darwin Hospital (AU)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-11-12
- DOI
- https://doi.org/10.5281/zenodo.24089864
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00