Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Bladder Cancer Patients Undergoing Radical Cystectomy: A Systematic Review and Meta-Analysis

Poster and supplementary figures presented at the Millin Meeting, Royal College of Surgeons in Ireland, Dublin, 12-13 November 2026. Systematic review and meta-analysis of the neutrophil-to-lymphocyte ratio (NLR) and survival after radical cystectomy for bladder cancer (38 studies, 12,917 patients; PROSPERO CRD420261399528). High versus low NLR was associated with worse overall survival (HR 1.77, 95% CI 1.41-2.22, 15 studies), cancer-specific survival (HR 1.73, 1.20-2.49) and recurrence-free survival (HR 1.61, 1.07-2.42). Each one-unit rise in NLR was associated with worse overall survival (HR 1.08, 1.05-1.10). The supplementary PDF contains the overall-survival forest plot, a summary table of all analyses, the characteristics of each meta-analysed study, the secondary forest plots, sensitivity analyses, the cut-off used by each study and the PRISMA flow diagram. Not peer reviewed.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-12
DOI
https://doi.org/10.5281/zenodo.24089864
Primary Topic
Inflammatory Biomarkers in Disease Prognosis
Type
article
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article

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Bladder Cancer Patients Undergoing Radical Cystectomy: A Systematic Review and Meta-Analysis

Rowan G. Casey, Peter Lawlor, Gavin G. Calpin, Cian Hehir et al.
Zenodo (CERN European Organization for Nuclear Research)
Inflammatory Biomarkers in Disease Prognosis
article

Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Bladder Cancer Patients Undergoing Radical Cystectomy: A Systematic Review and Meta-Analysis

Rowan G. Casey, Peter Lawlor, Gavin G. Calpin, Cian Hehir, Zachary Thompson, Emma Powell
article en

Abstract

Poster and supplementary figures presented at the Millin Meeting, Royal College of Surgeons in Ireland, Dublin, 12-13 November 2026. Systematic review and meta-analysis of the neutrophil-to-lymphocyte ratio (NLR) and survival after radical cystectomy for bladder cancer (38 studies, 12,917 patients; PROSPERO CRD420261399528). High versus low NLR was associated with worse overall survival (HR 1.77, 95% CI 1.41-2.22, 15 studies), cancer-specific survival (HR 1.73, 1.20-2.49) and recurrence-free survival (HR 1.61, 1.07-2.42). Each one-unit rise in NLR was associated with worse overall survival (HR 1.08, 1.05-1.10). The supplementary PDF contains the overall-survival forest plot, a summary table of all analyses, the characteristics of each meta-analysed study, the secondary forest plots, sensitivity analyses, the cut-off used by each study and the PRISMA flow diagram. Not peer reviewed.

Zenodo (CERN European Organization for Nuclear Research)
Royal College of Surgeons in Ireland (IE), Ollscoil na Gaillimhe – University of Galway (IE), Tallaght University Hospital (IE), Royal Darwin Hospital (AU)
Inflammatory Biomarkers in Disease Prognosis
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