Asymmetric Construction of Chiral β-Aminoketone Derivatives via Enantioselective Mannich/Retro-Claisen Cascade Reaction
Abstract Herein, we report an organocatalytic asymmetric Mannich addition/retro-Claisen cascade reaction between unsymmetrical 1,3-diones and in situ-generated N-Boc-protected alkynylimines, affording chiral β-aminoketone derivatives in good yields with high enantioselectivities. The obtained chiral β-aminoketone derivatives can be readily transformed into hydrogenated products and oxime derivatives, respectively.
Authors
- Wenling Qin (ORCID: https://orcid.org/0000-0002-5654-5785)
- Weijun Yao (ORCID: https://orcid.org/0000-0001-6463-2937)
- Qingqin Huang (ORCID: https://orcid.org/0000-0003-3700-3101)
- Wenhui Wang (ORCID: https://orcid.org/0000-0003-0433-0261)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-1165-2552)
- Yu Zhang
Institutions
- Zhejiang Sci-Tech University (CN)
- Chongqing University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-11-11
- DOI
- https://doi.org/10.1021/acs.joc.6c02112
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00