A Multimodal Nano-Vehicle for the Transport of Biologically Active Amine Oxidase as a Therapeutic Enzyme

High polyamine (PA) concentration due to altered metabolism represents an Achilles’ heel in targeting PA-rich cancerous cells. This is due to the possibility of generating toxic by-products via the amine oxidase (AO)-catalyzed oxidation of PA. Nevertheless, AO intracellular delivery remains an open challenge. Recently, an extensive study on Caco-2 cells showed the applicability of a new magnetic and fluorescent nanoparticle (SAMN@TA) as a bovine serum amino oxidase (BSAO) carrier. Here, a SAMN@TA@BSAO multimodal nano-device was tested on two different human colorectal adenocarcinoma cell lines (LoVo WT and DX), confirming remarkable cell association along with a dose-dependent loss of cell viability, reaching 43% and 60% per single treatment, respectively. This contribution stimulates further investigation on SAMN@TA@BSAO use as a potential anticancer tool.

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Publication Details

Journal
International Journal of Molecular Sciences
Published
2026-11-11
DOI
https://doi.org/10.3390/ijms272210090
Primary Topic
Nanoparticle-Based Drug Delivery
Type
article
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article

A Multimodal Nano-Vehicle for the Transport of Biologically Active Amine Oxidase as a Therapeutic Enzyme

Graziano Rilievo, Lavinia Rutigliano, Massimiliano Magro, Pasquale Fino et al.
International Journal of Molecular Sciences
Nanoparticle-Based Drug Delivery
article

A Multimodal Nano-Vehicle for the Transport of Biologically Active Amine Oxidase as a Therapeutic Enzyme

Graziano Rilievo, Lavinia Rutigliano, Massimiliano Magro, Pasquale Fino, Fábio Vianello, Enzo Agostinelli, Federica Tonolo, Alessandro Cecconello, Alberto Macone, Aura Cencini, Mary Bortoluzzi
article en

Abstract

High polyamine (PA) concentration due to altered metabolism represents an Achilles’ heel in targeting PA-rich cancerous cells. This is due to the possibility of generating toxic by-products via the amine oxidase (AO)-catalyzed oxidation of PA. Nevertheless, AO intracellular delivery remains an open challenge. Recently, an extensive study on Caco-2 cells showed the applicability of a new magnetic and fluorescent nanoparticle (SAMN@TA) as a bovine serum amino oxidase (BSAO) carrier. Here, a SAMN@TA@BSAO multimodal nano-device was tested on two different human colorectal adenocarcinoma cell lines (LoVo WT and DX), confirming remarkable cell association along with a dose-dependent loss of cell viability, reaching 43% and 60% per single treatment, respectively. This contribution stimulates further investigation on SAMN@TA@BSAO use as a potential anticancer tool.

International Journal of Molecular SciencesVol. 27(22)
University of Padua (IT), Policlinico Umberto I (IT), International Flame Research Foundation (IT), University of Brescia (IT), Sapienza University of Rome (IT)
Nanoparticle-Based Drug Delivery
DOIOpen Access PDFOpenAlex
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A Multimodal Nano-Vehicle for the Transport of Biologically Active Amine Oxidase as a Therapeutic Enzyme — Graziano Rilievo, Lavinia Rutigliano, et al. · International Journal of Molecular Sciences (2026) | TGRS Research Map | TGRS