Proposed approach for diagnosing obesity outperforms old method

A framework for diagnosing obesity that was proposed in 2025 incorporates waist circumference and related measures and distinguishes clinical from preclinical obesity on the basis of obesity-induced organ dysfunction. In an international multi-cohort study of 844,108 adults, this framework outperformed conventional body-mass-index-based criteria in diagnosing obesity and stratifying mortality risk. A combination of body and organ-function metrics does better at classifying obesity than does body mass index.

Publication Details

Journal
Nature
Published
2026-11-11
DOI
https://doi.org/10.1038/d41586-026-03425-0
Primary Topic
Obesity, Physical Activity, Diet
Type
article
Field-Weighted Citation Impact
0.00
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article

Proposed approach for diagnosing obesity outperforms old method

Nature
Obesity, Physical Activity, Diet
article

Proposed approach for diagnosing obesity outperforms old method

article en

Abstract

A framework for diagnosing obesity that was proposed in 2025 incorporates waist circumference and related measures and distinguishes clinical from preclinical obesity on the basis of obesity-induced organ dysfunction. In an international multi-cohort study of 844,108 adults, this framework outperformed conventional body-mass-index-based criteria in diagnosing obesity and stratifying mortality risk. A combination of body and organ-function metrics does better at classifying obesity than does body mass index.

Nature
Obesity, Physical Activity, Diet
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Proposed approach for diagnosing obesity outperforms old method · Nature (2026) | TGRS Research Map | TGRS