Lipid Accumulation Product Is Associated with an Adverse Inflammatory and Adipokine Profile in Middle-Aged Women

Background: Visceral adiposity is closely linked to chronic low-grade inflammation and adipokine dysregulation, but these relationships remain incompletely characterized in middle-aged women. This study examined associations between the Lipid Accumulation Product (LAP), systemic inflammatory biomarkers, and adiponectin in middle-aged women. Methods: This cross-sectional study included 107 middle-aged women. LAP was calculated from waist circumference and fasting triglycerides. Serum high-sensitivity C-reactive protein (hs-CRP) and adiponectin were considered primary outcomes, whereas high-sensitivity interleukin-6 (hs-IL-6) and tumor necrosis factor-α (TNF-α) were exploratory secondary outcomes. Associations were assessed using correlation analyses and sequential linear models adjusted for age, physical activity, and the Energy-adjusted Dietary Inflammatory Index (E-DII). Results: Higher LAP was associated with higher hs-CRP (Spearman’s ρ = 0.430, p < 0.001) and lower adiponectin (ρ = −0.405, p < 0.001). In fully adjusted models, LAP remained positively associated with ln(hs-CRP) after multivariable adjustment (β = 0.364, B = 0.01276, 95% CI: 0.00574 to 0.01978, p < 0.001) and inversely associated with ln(adiponectin) (β = −0.379, B = −0.00453, 95% CI: −0.00685 to −0.00221, p < 0.001). Positive associations of LAP with hs-IL-6 and TNF-α were also observed in exploratory adjusted analyses. Additional adjustment for BMI or body fat percentage attenuated the LAP–hs-CRP association, which was no longer statistically significant, whereas the inverse LAP–adiponectin association remained significant. Conclusions: Higher LAP values were associated with higher hs-CRP and lower adiponectin concentrations after adjustment for age, physical activity, and dietary inflammatory potential. However, the LAP–hs-CRP association was no longer statistically significant after additional adjustment for BMI or body fat percentage, whereas the LAP–adiponectin association remained significant. These findings suggest that LAP is associated with an adverse inflammatory and adipokine profile in middle-aged women; however, its incremental clinical value beyond conventional anthropometric and biochemical measures remains to be established.