TRIM13 (tripartite motif-containing 13) improves mitophagy of dendritic cells via promoting SESN2 (sestrin 2)-induced K63-linked ubiquitination in sepsis

AF: AlphaFold; BECN1: beclin 1, autophagy related; CLP: cecal ligation and puncture; co-IP: co-immunoprecipitation; DAMPs: danger/damageassociated molecular patterns; DCs: dendritic cells; DEGs: differentially expressed genes; FUNDC1: FUN14 domain containing 1; IL: interleukin; LPS: lipopolysaccharide; MAMs: mitochondria-associated membranes; MAP1LC3B/LC3B: microtubule associated protein 1 light chain 3 beta; MHC: major histocompatibility complex; MLKL: mixed lineage kinase domain-like; Nec-1: necrostatin-1; PBMCs: peripheral blood mononuclear cells; RIPK3: receptor-interacting serine-threonine kinase 3; SESN2: sestrin 2; SIRT1: sirtuin 1; SQSTM1/p62: sequestosome 1; TEM: transmission electron microscopy; TLR: toll-like receptor; TNF: tumor necrosis factor; TRAF6: TNF receptor-associated factor 6; TRIM13: tripartite motif-containing 13; ULK1: unc-51 like kinase 1; UPR: unfolded protein response; UPS: ubiquitinproteasome system; WT: wild-type.