GWAS-by-Subtraction Reveals Obesity-Related and Obesity-Independent Genetic Pathways in Osteoarthritis

This repository provides GWAS summary statistics, analysis scripts, and supporting results from a GWAS-by-subtraction study of osteoarthritis (OA) and body mass index (BMI). Using Genomic SEM, OA genetic liability was partitioned into obesity-related (FOB) and obesity-independent (FNonOB) components. The files include factor-specific GWAS results, lead variants, fine-mapping, TWAS, PWAS, colocalization, pathway enrichment, single-cell analyses, and scripts supporting reproducibility of the findings.