A Granularity Blind Spot in the Evaluation of SNOMED CT Concept Normalization

Abstract Background. Clinical concept normalization maps free-text mentions to terminology codes but is usually evaluated with aggregate exact match and a binary seen/novel split. These summaries do not distinguish mentions recorded as finer-grained than their assigned code. Using native granularity labels in three Spanish SNOMED CT corpora, we tested whether exact-match error incidence differs between NARROW and EXACT reference strata across up to five lexical, neural and generative systems. Results. Systems failed to reproduce the corpus-assigned code under exact match more often for NARROW mentions (finer-grained than their assigned code) than for EXACT mentions (panel-weighted Mantel–Haenszel risk ratio 1.72, 95% CI 1.63–1.83). The Wu–Palmer-minus-exact credit gap was larger on NARROW mentions in all 14 system×benchmark cells (geometric mean ratio 1.87, 95% CI 1.71–2.05), driven by error incidence rather than a consistent difference in conditional error proximity. In the pooled Qwen analysis, sibling and cousin predictions contributed 56–67% of summed Wu–Palmer credit among non-exact predictions. Under a stricter same-lineage criterion, the uplift beyond exact match was larger for NARROW mentions in 9 of 14 cells. The larger graded gap retained its direction under alternative metrics, candidate spaces and xMEN. Graph-refined novelty classified 825 of 982 code-novel DisTEMIST mentions (84.0%) as ancestor-seen; the remaining 157 were fully isolated (6.3% of all 2,507 mentions). Majority-vote consensus in the blinded three-rater audit agreed with the corpus labels for 130 of 150 mentions (κ = 0.73). Conclusions. Aggregate exact match obscures a benchmark-relative difference between reference-granularity strata. For benchmarks with granularity labels, granularity-stratified exact-match error rates should be reported first; hierarchy-aware scores should be paired with relation types.

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Publication Details

Journal
Research Square
Published
2026-11-11
DOI
https://doi.org/10.21203/rs.3.rs-10602575/v1
Primary Topic
Biomedical Text Mining and Ontologies
Type
preprint
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preprint

A Granularity Blind Spot in the Evaluation of SNOMED CT Concept Normalization

Yoojin Nam, Pa Hong, Eunji Kim, Yejin Jo et al.
Research Square
Biomedical Text Mining and Ontologies
preprint

A Granularity Blind Spot in the Evaluation of SNOMED CT Concept Normalization

Yoojin Nam, Pa Hong, Eunji Kim, Yejin Jo, YangWon Kim
preprint en

Abstract

Abstract Background. Clinical concept normalization maps free-text mentions to terminology codes but is usually evaluated with aggregate exact match and a binary seen/novel split. These summaries do not distinguish mentions recorded as finer-grained than their assigned code. Using native granularity labels in three Spanish SNOMED CT corpora, we tested whether exact-match error incidence differs between NARROW and EXACT reference strata across up to five lexical, neural and generative systems. Results. Systems failed to reproduce the corpus-assigned code under exact match more often for NARROW mentions (finer-grained than their assigned code) than for EXACT mentions (panel-weighted Mantel–Haenszel risk ratio 1.72, 95% CI 1.63–1.83). The Wu–Palmer-minus-exact credit gap was larger on NARROW mentions in all 14 system×benchmark cells (geometric mean ratio 1.87, 95% CI 1.71–2.05), driven by error incidence rather than a consistent difference in conditional error proximity. In the pooled Qwen analysis, sibling and cousin predictions contributed 56–67% of summed Wu–Palmer credit among non-exact predictions. Under a stricter same-lineage criterion, the uplift beyond exact match was larger for NARROW mentions in 9 of 14 cells. The larger graded gap retained its direction under alternative metrics, candidate spaces and xMEN. Graph-refined novelty classified 825 of 982 code-novel DisTEMIST mentions (84.0%) as ancestor-seen; the remaining 157 were fully isolated (6.3% of all 2,507 mentions). Majority-vote consensus in the blinded three-rater audit agreed with the corpus labels for 130 of 150 mentions (κ = 0.73). Conclusions. Aggregate exact match obscures a benchmark-relative difference between reference-granularity strata. For benchmarks with granularity labels, granularity-stratified exact-match error rates should be reported first; hierarchy-aware scores should be paired with relation types.

Research Square
Asan Medical Center (KR), University of Ulsan (KR), Samsung Changwon Hospital (KR), Sungkyunkwan University (KR)
Biomedical Text Mining and Ontologies
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