Phytochemical profile and pharmacological modulation of lafoensia pacari in wound healing and inflammatory response

The present study aimed to gather, analyze, and critically discuss scientific evidence concerning the phytochemical profile and pharmacological properties of Lafoensia pacari, with emphasis on the major secondary metabolites identified, particularly phenolic compounds, flavonoids, tannins, and ellagic acid, and their potential involvement in inflammatory processes, wound healing, angiogenesis, and genotoxicological safety. The methodological approach was based on an integrative analysis of recent scientific literature concerning secondary metabolites present in the leaves and bark of the plant, highlighting the occurrence of phenolic compounds, flavonoids, and ellagic acid. The evidence reviewed suggests that these bioactive constituents may act synergistically to reduce oxidative stress, modulate reactive oxygen species, and regulate cellular pathways involved in tissue regeneration and cutaneous wound re-epithelialization. It is concluded that the traditional use of Lafoensia pacari is supported by pharmacological evidence and molecular mechanisms described in the scientific literature, indicating its therapeutic potential for the development of herbal medicinal products with anti-inflammatory and wound-healing properties. However, further experimental investigations are needed, particularly regarding therapeutic efficacy, angiogenic activity, and toxicological, genotoxic, and mutagenic safety, before its clinical application.