Terapia antirretroviral na terceira idade: manejo das interações medicamentosas

Antiretroviral therapy in older adults presents specific challenges arising from both the physiological changes associated with aging and the high prevalence of comorbidities that lead to polypharmacy. These factors directly affect the pharmacokinetics and pharmacodynamics of medications, increasing the risk of drug interactions and adverse events that may compromise therapeutic efficacy. In this context, understanding how these interactions occur and their impact on treatment adherence is essential to promoting safer care. Accordingly, this study analyzes the main medications used by older adults receiving antiretroviral therapy and their potential interactions, while also exploring their implications for quality of life and treatment success. Based on a critical synthesis of the selected literature, strategies aimed at optimizing clinical management, reducing polypharmacy-related risks, and strengthening treatment adherence are discussed, as adherence is an essential factor in achieving sustained viral suppression. This analysis is expected to contribute to the development of evidence-based clinical practices, supporting more individualized interventions tailored to the needs of this population, whose clinical complexity requires continuous monitoring and a multidimensional approach.