mGluR bioactivity curation and split audit: frozen pre-specification v1.0 and Amendment 1 (scope rewrite)

Frozen research protocol for an audit of how bioactivity curation policy and train/test split policy affect predictive model performance on metabotropic glutamate receptor data from ChEMBL and UniProt, centred on human mGluR5. Contains the Round 1 pre-specification v1.0 frozen 2026-11-11, Amendment 1 (scope rewrite) signed 2026-11-11, and the Round 1 consolidated report.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-11
DOI
https://doi.org/10.5281/zenodo.24138427
Primary Topic
Computational Drug Discovery Methods
Type
article
Field-Weighted Citation Impact
0.00
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article

mGluR bioactivity curation and split audit: frozen pre-specification v1.0 and Amendment 1 (scope rewrite)

Luis Escamilla
Zenodo (CERN European Organization for Nuclear Research)
Computational Drug Discovery Methods
article

mGluR bioactivity curation and split audit: frozen pre-specification v1.0 and Amendment 1 (scope rewrite)

Luis Escamilla
article en

Abstract

Frozen research protocol for an audit of how bioactivity curation policy and train/test split policy affect predictive model performance on metabotropic glutamate receptor data from ChEMBL and UniProt, centred on human mGluR5. Contains the Round 1 pre-specification v1.0 frozen 2026-11-11, Amendment 1 (scope rewrite) signed 2026-11-11, and the Round 1 consolidated report.

Zenodo (CERN European Organization for Nuclear Research)
Computational Drug Discovery Methods
DOIOpen Access PDFOpenAlex
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mGluR bioactivity curation and split audit: frozen pre-specification v1.0 and Amendment 1 (scope rewrite) — Luis Escamilla · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS