Factors associated with TAK-003 dengue vaccine acceptance among Thai adults using the Health Belief Model and Theory of Planned Behavior in a tertiary care hospital

Although the live-attenuated tetravalent dengue vaccine (TAK-003) is now available in Thailand, evidence on the behavioral determinants of its acceptance remains limited. We assessed TAK-003 vaccine acceptance, identified factors associated with acceptance using the Health Belief Model and Theory of Planned Behavior frameworks, and evaluated willingness to pay. We conducted a cross-sectional survey from December 2025 to February 2026. Thai adults aged 18–60 years who had never received a dengue vaccine were included and recruited through convenience sampling at Siriraj Hospital, Bangkok. Factors associated with vaccine acceptance were identified using multivariable binary logistic regression. A total of 448 participants were included, of whom 46.7% ( n = 209) accepted the TAK-003 vaccine. In the adjusted model, participants aged 50–60 years (adjusted Odd ratio (aOR) = 2.61, 95% CI: 1.33–5.11), those with a history of dengue infection (aOR = 2.61, 95% CI: 1.56–4.35), greater perceived susceptibility (aOR = 1.57, 95% CI: 1.02–2.41), greater perceived benefits (aOR = 2.57, 95% CI: 1.44–4.60), stronger cues to action (aOR = 2.33, 95% CI: 1.20–4.55), and more positive attitudes toward the vaccine (aOR = 1.74, 95% CI: 1.06–2.84) were significantly associated with vaccine acceptance. Approximately 42.9% ( n = 192) of participants were willing to pay ≤500 THB per vaccine dose. These findings may inform local strategies for communicating dengue risk and vaccine benefits and addressing affordability of TAK-003 vaccination.