Structural Characterization of 1-(2-(2,8-bis(Trifluoromethyl)quinolin-4-yl)-2-hydroxyethyl)pyrrolidin-2-one: An Unexpected Cyclization Product
1-(2-(2,8-bis(Trifluoromethyl)quinolin-4-yl)-2-hydroxyethyl)pyrrolidin-2-one has been synthesized through a multi-step pathway starting from commercially available 4-hydroxy-2,8-bis(trifluoromethyl)quinoline. Structural characterization of this original substituted mefloquine derivative was achieved using FT-IR, 1H-NMR, 13C-NMR and single-crystal X-Ray diffraction analysis.
Authors
- Jean Guillon (ORCID: https://orcid.org/0000-0001-8577-3894)
- Hugo Bloux (ORCID: https://orcid.org/0000-0002-4209-4979)
- Mathieu Marchivie (ORCID: https://orcid.org/0000-0003-1362-0797)
- Alexandra Dassonville‐Klimpt (ORCID: https://orcid.org/0000-0002-2891-9102)
- Pascal Sonnet (ORCID: https://orcid.org/0000-0003-0118-9151)
- Noël Pinaud (ORCID: https://orcid.org/0000-0001-7646-5312)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Inserm (FR)
- Institut des Sciences Moléculaires (FR)
- Institut de Chimie de la Matière Condensée de Bordeaux (FR)
- Laboratoire de l'Intégration du Matériau au Système (FR)
- Institut Polytechnique de Bordeaux (FR)
- Acides nucléiques: Régulations naturelles et artificielles (FR)
- Agents infectieux, résistance et chimiothérapie (FR)
- Université de Picardie Jules Verne (FR)
Publication Details
- Journal
- Molbank
- Published
- 2026-11-10
- DOI
- https://doi.org/10.3390/m2256
- Primary Topic
- Crystal structures of chemical compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00