Analytical Study of Kharjuradi Leha and Kharjuradi Khandapaka

Background: Pharmaceutical modification of an Ayurvedic formulation may alter moisture content, concentration, physical properties and handling.Objective: To compare the analytical observations recorded for Kharjuradi Leha and its modified granular form, Kharjuradi Khandapaka.Methods: Thesis-reported results for pH, loss on drying, ash values, sugar estimation, thin-layer chromatography (TLC), micromeritic properties and microbial counts were collated.Results: pH was 4.82 for Leha and 5.71 for Khandapaka. Loss on drying was 15.70% and 7.63%; total ash 5.85% and 2.69%; acid-insoluble ash 4.19% and 1.44%, respectively. Reducing sugar was 13.38% and 10.87%, while non-reducing sugar was 4.05% and 5.73%. TLC showed prominent spots at Rf 0.70 and 0.62 for Leha and 0.89, 0.80 and 0.62 for Khandapaka. Khandapaka bulk density was 0.654 g/mL and compressibility index was 24.37%. TAMC and TYMC were reported below 10² CFU/g in both samples.Conclusion: The two dosage forms showed measurable differences in the recorded parameters.