Clinical Evaluation of Skin Moisturization, Dryness, Roughness and TEWL Following a Single Application of a Novel Panthenol plus Bisabolol-enhanced Cream and Lotion

Background: Daily moisturization is a foundational intervention for restoring and maintaining skin barrier integrity. Studies demonstrate that regular topical application of moisturizers (lotions and creams) increases stratum corneum hydration and, when appropriately formulated, lowers transepidermal water loss (TEWL), accelerating barrier recovery. Despite this evidence, suboptimal patient adherence limits real-world use, with patient-reported adherence ranging from approximately 51-90%, and satisfaction with symptom control frequently reported as low. Formulation is critical in generation of products that are appropriate for barrier hydration and repair, and soothing enough for daily use and adherence. Objectives: We describe here the clinical evaluation of a novel panthenol plus bisabolol-enhanced lotion and cream aimed at maximal skin hydration and smoothness following a single application. Materials and Methods: A single-center, double-blind, controlled study on subjects with Fitzpatrick Skin Types I-VI and mild or moderate dry skin (n=30) on the lower legs was conducted. Subjects applied one single application of the lotion (Aquaphor Hydrating Daily Lotion) or cream (Aquaphor Moisturizing Cream) to either the lower left or lower right leg; subjects’ untreated legs were used as controls. Assessments, including clinical grading, corneometer measurements, and tewameter measurements were conducted at baseline, 15 minutes, 24 hours, 48 hours, and 72 hours post-application. Monitoring of adverse events were evaluated throughout the study period. Results: Immediate (15 minutes post-application) and long-lasting (up to 72 hours post-application) improvements in skin dryness, moisturization, and roughness were demonstrated following a single application of either the panthenol and bisabolol-enhanced lotion and cream. Improvement in TEWL was measured as early as 15 minutes post-application of either the panthenol and bisabolol-enhanced lotion and cream. Both products were well tolerated throughout the study period. Conclusions: Panthenol and bisabolol have been previously demonstrated to be integral ingredients in semi-occlusive healing ointments. The clinical evaluation of two novel formulations (lotion and cream) which include hyaluronic acid, ceramides, glycerin, and vitamin E enhanced with panthenol and bisabolol demonstrated immediate and long-lasting improvements in skin dryness, roughness, and moisturization, with immediate improvement in TEWL. These two novel formulations may play an integral part in daily hydration, skin protection and maintenance, aimed at improving patient adherence. Dermatology HCPs should consider these products as part of their overall skin health treatment recommendations. Scientific Poster support provided by Beiersdorf, Inc.