Bridging Soviet Unloading-Dietary Therapy (RDT) Clinical Cohorts to Human Circadian-Metabolic Pathways: A Cross-Lingual Systems-Biology Synthesis of the Day 5-7 Acidotic Crisis

Cross-lingual translation and systems-biology pathway enrichment of Soviet/Russian Unloading-Dietary Therapy (Разгрузочно-диетическая терапия, RDT) clinical cohorts (Nikolayev, Kokosov, Goryachinsk) mapped to the 2026 Reactome Human Pathway Database, identifying AMPK/SIRT1/PGC-1a-driven transcriptional resetting of the RORA/REV-ERBa (R-HSA-9933387) and BMAL1/CLOCK (R-HSA-9931509) master circadian oscillator as the molecular correlate of the Day 5-7 Acidotic Crisis.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-10
DOI
https://doi.org/10.5281/zenodo.24119822
Primary Topic
Circadian rhythm and melatonin
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
NOV
article

Bridging Soviet Unloading-Dietary Therapy (RDT) Clinical Cohorts to Human Circadian-Metabolic Pathways: A Cross-Lingual Systems-Biology Synthesis of the Day 5-7 Acidotic Crisis

Corey Chappell
Zenodo (CERN European Organization for Nuclear Research)
Circadian rhythm and melatonin
article

Bridging Soviet Unloading-Dietary Therapy (RDT) Clinical Cohorts to Human Circadian-Metabolic Pathways: A Cross-Lingual Systems-Biology Synthesis of the Day 5-7 Acidotic Crisis

Corey Chappell
article en

Abstract

Cross-lingual translation and systems-biology pathway enrichment of Soviet/Russian Unloading-Dietary Therapy (Разгрузочно-диетическая терапия, RDT) clinical cohorts (Nikolayev, Kokosov, Goryachinsk) mapped to the 2026 Reactome Human Pathway Database, identifying AMPK/SIRT1/PGC-1a-driven transcriptional resetting of the RORA/REV-ERBa (R-HSA-9933387) and BMAL1/CLOCK (R-HSA-9931509) master circadian oscillator as the molecular correlate of the Day 5-7 Acidotic Crisis.

Zenodo (CERN European Organization for Nuclear Research)
Circadian rhythm and melatonin
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Laika access coming soon
Bridging Soviet Unloading-Dietary Therapy (RDT) Clinical Cohorts to Human Circadian-Metabolic Pathways: A Cross-Lingual Systems-Biology Synthesis of the Day 5-7 Acidotic Crisis — Corey Chappell · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS