Automated MKB-10 Triage and Clinical Documentation in Thyroid Care Study

High-volume specialized endocrine centers face operational bottlenecks in manual ICD-10 (MKB-10) coding, clinical documentation, and diagnostic triage. This study evaluates an automated machine learning decision support architecture deployed across a retrospective dataset of 30,000 patient encounters at the Čigota Institute. Methods: We validated a multi-output classification and natural language processing pipeline trained on structured clinical parameters and diagnostic records. Performance was evaluated using standard metrics, including macro-averaged AUROC, subset accuracy, weighted F1-score, and targeted recall for critical diagnostic codes. Results: The system achieved a Macro AUROC of 0.9597, a Subset Accuracy of 0.7820, and a Weighted F1-score of 0.7948 across all triage categories. For high-risk malignant thyroid pathology (MKB-10 code C73), the model demonstrated a Recall of 0.9805 (98.05%) and a Precision of 0.9542. Conclusion: The validation results confirm that machine-learning-assisted triage and documentation systems can provide highly accurate, scalable decision support in specialized clinical environments while maintaining exceptionally high sensitivity for critical oncological diagnoses.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-10
DOI
https://doi.org/10.5281/zenodo.24117550
Primary Topic
Machine Learning in Healthcare
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article
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article

Automated MKB-10 Triage and Clinical Documentation in Thyroid Care Study

Simic Aleksandar, Nikola Derikonjic
Zenodo (CERN European Organization for Nuclear Research)
Machine Learning in Healthcare
article

Automated MKB-10 Triage and Clinical Documentation in Thyroid Care Study

Simic Aleksandar, Nikola Derikonjic
article en

Abstract

High-volume specialized endocrine centers face operational bottlenecks in manual ICD-10 (MKB-10) coding, clinical documentation, and diagnostic triage. This study evaluates an automated machine learning decision support architecture deployed across a retrospective dataset of 30,000 patient encounters at the Čigota Institute. Methods: We validated a multi-output classification and natural language processing pipeline trained on structured clinical parameters and diagnostic records. Performance was evaluated using standard metrics, including macro-averaged AUROC, subset accuracy, weighted F1-score, and targeted recall for critical diagnostic codes. Results: The system achieved a Macro AUROC of 0.9597, a Subset Accuracy of 0.7820, and a Weighted F1-score of 0.7948 across all triage categories. For high-risk malignant thyroid pathology (MKB-10 code C73), the model demonstrated a Recall of 0.9805 (98.05%) and a Precision of 0.9542. Conclusion: The validation results confirm that machine-learning-assisted triage and documentation systems can provide highly accurate, scalable decision support in specialized clinical environments while maintaining exceptionally high sensitivity for critical oncological diagnoses.

Zenodo (CERN European Organization for Nuclear Research)
Machine Learning in Healthcare
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