Programmable White Blood Cells: A Two-Marker Specificity-Logic Design for Engineered T Cells

Design paper (SIMULATED, NOT MEASURED) specifying a two-marker AND-gate specificity logic for engineered T cells: a priming receptor for one disease marker induces a killing receptor for a second, so firing requires both markers on the same target cell. Occupancy modelling gives a discrimination ratio of 25.0 versus 2.5 for a single-receptor design, with computed dose, expansion, cytokine-risk, persistence, and antigen-escape budgets, failure modes, and quantitative stopping conditions. All numbers are outputs of the accompanying computation script. Nothing is described as built or tested.