A Kinetic Study on the Solvent Effect of Aquo-DMSO Solvent Systems on the Medicinal Efficiencies of Cinnamate Esters

With a view to study the Solvent effect of dipolar-aprotic solvent on the. medicinal efficiency of an unsaturated acid ester (Cinnamate), the kinetics of alkali catalysed hydrolysis of methyl cinnamate was studied in aquoDMSO Solvent System. From enhancement in ∆H* and ∆S* values with simultaneous increase in ∆G* values of the reaction, it has been inferred that the reaction is enthalpy dominated and entropy controlled. From the enhancement in EC values with increase in DMSO content in the reaction media and from depletion in ED values with increase in D values of the aquoDMSO media, it has been concluded that the initial state and the transition state of the reaction are solvated and desolvated respectively.