Biopharmaceutical Behaviour of Everolimus in Hydrophobic and Hydrophilic Solvents

This paper explores the biopharmaceutical behaviours of Everolimus in various solvent systems, with an emphasis on hydrophobic and hydrophilic solvents, such as ethanol, methanol, dichloromethane (DCM), acetonitrile, and dimethyl sulfoxide (DMSO). The solubility, stability, and formulation strategies associated with different solvent combinations are discussed in relation to enhancing the solubility of Everolimus, a poorly water-soluble drug. By investigating the physicochemical properties of Everolimus through solvent solubility techniques, the study aims to support formulation and pre-formulation development, dose analysis, and batch testing, while examining the impact of solubility on drug stability. Utilizing solid material preparation techniques, this research provides foundational documentation for the creation of new dosage forms, testing methodologies, and innovations within the pharmaceutical and medical device industries. The findings are pivotal for pre-formulation studies, dose development, and comprehensive physicochemical testing, including non-clinical analyses, providing a foundation for future pharmaceutical advancements.