ARTERIAL HYPERTENSION AND ERECTILE DYSFUNCTION: COMMON PATHOGENETIC MECHANISMS AND THERAPEUTIC POTENTIAL OF IRBESARTAN

Arterial hypertension (AH) and erectile dysfunction (ED) are interrelated clinical conditions whose pathogenesis involves endothelial dysfunction, reduced nitric oxide bioavailability, overactivation of the renin–angiotensin–aldosterone system (RAAS), oxidative stress, and impaired vascular regulation. The commonality of these mechanisms supports interest in the potential role of antihypertensive therapy, particularly angiotensin II receptor blockers (ARBs), including irbesartan, in patients with concomitant AH and ED.