Synthesis, characterization, and antioxidant activity of novel hydrazones of purine

A novel series of purine hydrazones (1-5) was synthesized in good yield from 6-chloropurine via the reaction with the corresponding hydrazone derivatives. All the synthesized compounds were characterized by spectral data, including FT-IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry, thereby confirming their structures. The synthesized compounds were screened for their antioxidant activity by the DPPH method. Compounds 2 and 3 exhibited the highest DPPH radical-scavenging activity among the synthesized derivatives. However, their activities were lower than those of the reference antioxidant ascorbic acid (IC₅₀ = 27.91 ± 0.84 µM). KEY WORDS: Hydrazones, Purines, Antioxidant activity, DPPH, Ascorbic acid Bull. Chem. Soc. Ethiop. 2027, 41(1), 183-190. DOI: https://dx.doi.org/10.4314/bcse.v41i1.12