Potential of synthetic 3-(naphthalen-2-yloxy)propan-2-ol derivatives for the control of parlatoria blanchardi with respect to their toxicological study

The current study aims to employ insecticides that are safer, more effective, and environmentally beneficial. In order to improve crop sustainability, pest control, and environmental safety, the majority of the target synthesized compounds were evaluated for their intrinsic activity against Parlatoria blanchardi nymphs and adults. The parlatoria date scale P. blanchardi was used to assess the efficacy of a recently manufactured chemical product in a lab setting. Indoxycarb was used as a reference pesticide. Here, the target product, 2-((2-naphthyloxy)methyl)oxirane 1a, was prepared by reacting epichlorohydrin with 2-naphthol in the presence of a suitable amount of sodium hydroxide as a catalyst. The synthetic oxirans 1a is treated with a variety of nucleophilic amines, when the latter reaction is conducted in the presence of triethyl amine as a catalyst. Spectral analyses, including IR, NMR, and elemental analyses, were used to characterize each new molecule. The results demonstrated that the target synthesized derivatives exhibited considerable insecticidal efficacy; compound 6 was shown to be more effective than the other compounds, with LC50 values of 0.927 ppm for adult female P. blanchardi and 0.323 ppm for nymphs. KEY WORDS: 2-((2-Naphthyloxy)methyl)oxirane, 2-Naphthol, Insecticidal evaluation, IGRs Bull. Chem. Soc. Ethiop. 2027, 41(1), 29-42. DOI: https://dx.doi.org/10.4314/bcse.v41i1.3