Cellular senescence: mechanisms, reversibility and research program (v3.1)

A broadened, traceable narrative synthesis on cellular senescence: what it is, the causal mechanisms that initiate and maintain it, how it is measured, and which interventions (senolytics, senomorphics, immune clearance, partial reprogramming, circulating factors) can slow or reverse its effects. It covers literature up to November 2026, including 2025-2026 human trials, negative results and retractions, with each claim marked [Verified], [Hypothesis] or [Unknown] and every reference checked by DOI. Short answer: some components of senescence can be modified in experimental models, but this dossier does not demonstrate a lasting, safe reversal of human aging; human signals remain limited by tissue and endpoint. The record contains the English document (PDF, 246 pages), the original French version (PDF, 255 pages), and reproducible research-team tools in English and French (scripts, data registers, sample-size calculations, SHA256 checksums; 34 automated checks pass). Use of AI: prepared with the assistance of artificial intelligence tools, under the editorial direction and responsibility of CEEDEXPRESS. Not medical advice: protocols are intended for qualified research teams under ethical and regulatory approval. No conflict of interest, no funding. Contact: [email protected]