Visible-Light-Induced Photoredox Anti-Markovnikov Hydroalkoxylation and Hydration of α‑Trifluoromethyl Alkenes
Herein, a visible-light-induced photoredox anti-Markovnikov hydroalkoxylation and hydration of α‑trifluoromethyl alkenes has been developed to give a straightforward access to structurally valuable β-trifluoromethyl ethers and alcohols. This robust protocol features synthetic advantages including facile metal-free and mild conditions, broad functional group tolerance, high chemoselectivity, and gram-scalability.
Authors
- Xiaochen Ji (ORCID: https://orcid.org/0000-0001-9533-0376)
- Huawen Huang (ORCID: https://orcid.org/0000-0001-7079-1299)
- Guo‐Jun Deng (ORCID: https://orcid.org/0000-0003-2759-0314)
- Jun Ying (ORCID: https://orcid.org/0000-0002-9578-2863)
- Dongfang Jiang (ORCID: https://orcid.org/0009-0006-3644-7519)
- Zhehao Xiao
Institutions
- Zhejiang Sci-Tech University (CN)
- Changsha Medical University (CN)
- Xiangtan University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-11-09
- DOI
- https://doi.org/10.1021/acs.joc.6c02328
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00