Second Look Lab — Research Brief: NO–cGMP pathway in ME/CFS & Long COVID

Computational drug-repurposing brief. Three independent screens (genetics, a long COVID ranking, and a literature hidden-link analysis) converge on the NO-sGC-cGMP vascular pathway in ME/CFS and long COVID, and highlight riociguat and nebivolol as untested follow-up candidates to the Charite vericiguat trial. Hypothesis only. Not medical advice. A SHA-256 hash of this PDF (60a68cb498496e31dd527a905fdba8ea3e9c50816c3017f558d990d46358a968) was timestamped with OpenTimestamps on 2026-11-08.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-08
DOI
https://doi.org/10.5281/zenodo.24078248
Primary Topic
Long-Term Effects of COVID-19
Type
preprint
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preprint

Second Look Lab — Research Brief: NO–cGMP pathway in ME/CFS & Long COVID

Second Look Lab
Zenodo (CERN European Organization for Nuclear Research)
Long-Term Effects of COVID-19
preprint

Second Look Lab — Research Brief: NO–cGMP pathway in ME/CFS & Long COVID

Second Look Lab
preprint en

Abstract

Computational drug-repurposing brief. Three independent screens (genetics, a long COVID ranking, and a literature hidden-link analysis) converge on the NO-sGC-cGMP vascular pathway in ME/CFS and long COVID, and highlight riociguat and nebivolol as untested follow-up candidates to the Charite vericiguat trial. Hypothesis only. Not medical advice. A SHA-256 hash of this PDF (60a68cb498496e31dd527a905fdba8ea3e9c50816c3017f558d990d46358a968) was timestamped with OpenTimestamps on 2026-11-08.

Zenodo (CERN European Organization for Nuclear Research)
Long-Term Effects of COVID-19
DOIOpen Access PDFOpenAlex
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Second Look Lab — Research Brief: NO–cGMP pathway in ME/CFS & Long COVID — Second Look Lab · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS