Redefining Success in Cancer Care: A Meaningful‐Life–Centred Framework for Precision Medicine

ABSTRACT Precision medicine has revolutionized cancer care by tailoring therapies to distinct tumour characteristics; however, therapeutic success is still predominantly evaluated through objective tumour response and survival endpoints that fail to capture the complete lived experience of patients. Here, we propose Meaningful‐Life–Centred Precision Oncology (MLCPO), a novel conceptual framework that integrates tumour biology with host physiology, functional reserve, individual priorities, psychosocial context and dynamic longitudinal reassessment across the entire cancer continuum. Rather than replacing established paradigms—such as shared decision‐making, patient‐reported outcomes, survivorship care and patient‐centred research—MLCPO synthesizes these elements into an adaptive, single‐decision architecture designed to help individuals live according to their personal values. We contextualize MLCPO alongside contemporary initiatives, including Common Sense Oncology and existing survivorship frameworks, and detail its practical implications for clinician education, clinical workflows, research design and health policy. Successful implementation demands moving beyond abstract calls for person‐centred care towards seamless workflow integration, objective quality metrics, authentic patient partnership, aligned financial incentives and strict system accountability for patient‐relevant outcomes. As a conceptual model, MLCPO requires multi‐stakeholder co‐design, operational specification and prospective clinical evaluation before its definitive effectiveness can be established.