A Community Engaged Feasibility Study of High-Risk Human Papillomavirus Self-Sampling for Cervical Cancer Screening in Sexual and Gender Minority People

BACKGROUND AND OBJECTIVES: We investigated the acceptability and feasibility of at-home self-sampling cervical cancer screening (CCS) for high-risk human papillomavirus (hrHPV) in sexual and gender minority (SGM) Kentuckians. METHODS: We conducted a descriptive qualitative study using virtual interviews to investigate socioecological factors influencing CCS and the feasibility and acceptability of at-home hrHPV self-sampling for primary CCS. Criterion and snowball sampling were used. Data were analyzed using a hybrid inductive-deductive thematic approach and team member consensus to identify salient themes. RESULTS: Nineteen participants completed hrHPV self-sampling and qualitative interviews in 2022-2023. The 6 overarching themes identified were cervical cancer screening perceptions, prior negative healthcare experiences, desirability of hrHPV self-sampling, completing hrHPV self-sampling, concerns about hrHPV self-sampling, and reasons for study participation. CONCLUSION: At-home hrHPV self-sampling is a promising intervention to increase CCS in SGM people. Individuals should be reassured that self-sampling is an effective method for primary CCS and that they are likely to be able to collect a sample that will yield accurate results. To maximize the possibility of CCS completion by SGM individuals, healthcare providers and healthcare environments must be affirming, culturally competent, and informed partners throughout the CCS process.