How has the definition of sepsis evolved over the years, and what are the major changes between Sepsis-1, Sepsis-2, and Sepsis-3 definitions?

The definition of sepsis has evolved from SIRS-based criteria (Sepsis-1 and Sepsis-2) to focus on organ dysfunction in Sepsis-3, aiding in more precise diagnosis and management.

Authors

Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-09
DOI
https://doi.org/10.5281/zenodo.24092435
Primary Topic
Sepsis Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

How has the definition of sepsis evolved over the years, and what are the major changes between Sepsis-1, Sepsis-2, and Sepsis-3 definitions?

Tripdatabase
Zenodo (CERN European Organization for Nuclear Research)
Sepsis Diagnosis and Treatment
article

How has the definition of sepsis evolved over the years, and what are the major changes between Sepsis-1, Sepsis-2, and Sepsis-3 definitions?

Tripdatabase
article en

Abstract

The definition of sepsis has evolved from SIRS-based criteria (Sepsis-1 and Sepsis-2) to focus on organ dysfunction in Sepsis-3, aiding in more precise diagnosis and management.

Zenodo (CERN European Organization for Nuclear Research)
Sepsis Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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How has the definition of sepsis evolved over the years, and what are the major changes between Sepsis-1, Sepsis-2, and Sepsis-3 definitions? — Tripdatabase · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS