When SOREMPs Meet Episodic Hypersomnia: REM Dysregulation as a Trait or State in Kleine–Levin Syndrome

REM dysregulation in Kleine-Levin syndrome may reflect a trait, an episode-dependent state, or profound hypersomnolence; SOREMPs should therefore be interpreted in the context of the longitudinal clinical phenotype.

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Publication Details

Journal
Neuropsychopharmacology Reports
Published
2026-11-08
DOI
https://doi.org/10.1002/npr2.70186
Primary Topic
Sleep and Wakefulness Research
Type
article
Field-Weighted Citation Impact
0.00
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article

When SOREMPs Meet Episodic Hypersomnia: REM Dysregulation as a Trait or State in Kleine–Levin Syndrome

Shinichiro M. Koga
Neuropsychopharmacology Reports
Sleep and Wakefulness Research
article

When SOREMPs Meet Episodic Hypersomnia: REM Dysregulation as a Trait or State in Kleine–Levin Syndrome

Shinichiro M. Koga
article en

Abstract

REM dysregulation in Kleine-Levin syndrome may reflect a trait, an episode-dependent state, or profound hypersomnolence; SOREMPs should therefore be interpreted in the context of the longitudinal clinical phenotype.

Neuropsychopharmacology ReportsVol. 46(4)
Tokyo University of Foreign Studies (JP), Japan Women's University (JP), Tokyo Metropolitan Komagome Hospital (JP)
Sleep and Wakefulness Research
DOIOpen Access PDFOpenAlex
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