Total Synthesis of Dehydromicrosclerodermin D
Abstract Dehydromicrosclerodermin D is a cyclic hexapeptide containing several unusual amino acids, isolated from the marine sponge Theonella cupola. The first total synthesis of this compound is described in a convergent approach, via a novel synthetic strategy that incorporates the key constituent α,β-unsaturated γ-amino acid residue in a masked form; the final step of the synthesis implicates a domino demasking-cyclization-dehydration sequence.
Authors
- Dayi Liu (ORCID: https://orcid.org/0000-0002-0251-6399)
- David J. Aitken (ORCID: https://orcid.org/0000-0002-5164-6042)
- Valérie Declerck (ORCID: https://orcid.org/0000-0003-0886-3911)
- Yongpeng Liu
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université Paris-Saclay (FR)
- Institut de Chimie Moléculaire et des Matériaux d'Orsay (FR)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-11-09
- DOI
- https://doi.org/10.1021/acs.orglett.6c04224
- Primary Topic
- Chemical Synthesis and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00