Association of DASH and Mediterranean Diet Adherence with Phase Angle in Patients with Crohn’s Disease: An Exploratory Cross-Sectional Study
Background/Objectives: Patients with Crohn’s disease (CD) are at increased risk of malnutrition, which may be reflected by reduced phase angle (PhA), a bioelectrical impedance marker of cellular integrity. This exploratory study investigated associations between Mediterranean and DASH diet adherence and PhA in adults with CD. Methods: This cross-sectional study included 39 adults with CD, mostly in clinical remission, from a Greek public hospital. PhA was measured by bioelectrical impedance analysis, and dietary quality was assessed with the MedDietScore and an adapted DASH score; the primary exposure was a food-based DASH index (seven food-group components), and the full 10-component score was exploratory. Associations were examined with multiple linear regression models adjusted for sex and physical activity. Results: After adjustment for sex and physical activity, each one-point higher food-based DASH index was associated with a 0.29° higher PhA, with a 95% CI from −0.003 to 0.588 (n = 35). In exploratory analyses, the full score, which includes qualitatively scored nutrient components, was also positively associated with PhA (B = 0.230, 95% CI 0.042–0.418). No clear association was observed for the total MedDietScore or full-fat dairy consumption. Conclusions: In adults with CD, the adjusted estimate for DASH-type food choices and PhA was positive but imprecise. These hypothesis-generating findings require confirmation in longitudinal and interventional studies.
Authors
- Sousana Κ. Papadopoulou (ORCID: https://orcid.org/0000-0002-6408-6128)
- Konstantinos Soufleris (ORCID: https://orcid.org/0000-0001-8635-6400)
- Constantinos Giaginis (ORCID: https://orcid.org/0000-0003-2878-4831)
- Gavriela Voulgaridou (ORCID: https://orcid.org/0009-0006-3850-058X)
- Paraskevi Detopoulou (ORCID: https://orcid.org/0000-0003-1723-9192)
- Olga Magni (ORCID: https://orcid.org/0009-0004-6545-1520)
- Konstantinos Papadimitriou (ORCID: https://orcid.org/0000-0002-0059-2873)
- Evangelia Paplomata
Institutions
- University of Peloponnese (GR)
- International Hellenic University (GR)
- Aristotle University of Thessaloniki (GR)
- Theageneio General Hospital (GR)
- University of the Aegean (GR)
Publication Details
- Journal
- Diseases
- Published
- 2026-11-08
- DOI
- https://doi.org/10.3390/diseases14110408
- Primary Topic
- Nutritional Studies and Diet
- Type
- article
- Field-Weighted Citation Impact
- 0.00