Research trends in the use of platelet-rich fibrin for periodontal regeneration: A bibliometric analysis

Aim: This study aimed to evaluate global research trends, scientific impact, collaboration patterns, and the knowledge structure of the literature on platelet-rich fibrin (PRF) in periodontal regeneration using bibliometric methods. Methodology: Publications related to PRF and periodontal regeneration were retrieved from the Web of Science Core Collection. The analysis included articles and review articles published up to December 31, 2025. Following the screening process, 271 publications were included. Publication trends, leading authors, journals, countries, institutions, citation patterns, and international research collaborations were evaluated. Author keyword co-occurrence analysis was performed to identify the major research themes and conceptual structure of the field. Results: The 271 publications received a total of 7,693 citations. Scientific output increased substantially over time, with the highest annual number of publications recorded in 2023 (n = 33); 55.0% of all publications were published between 2021 and 2025. India was the most productive country (n = 119), whereas the United States had the highest total link strength in the international collaboration network. Overall, 61 publications (22.5%) involved international collaboration. Keyword co-occurrence analysis identified 32 frequently occurring keywords grouped into three thematic clusters. The most prominent research themes were centered on platelet-rich fibrin, periodontal regeneration, periodontitis, intrabony defects, growth factors, and wound healing. Conclusion: Research on PRF in periodontal regeneration has expanded markedly, particularly in recent years. The findings demonstrate increasing scientific interest while revealing distinct patterns of geographic contribution, international collaboration, and thematic development. This bibliometric overview provides a comprehensive representation of the current knowledge structure of the field and may help identify areas for future research.