Topical therapies in acne vulgaris – A clinical review

Acne vulgaris affects the emotional and social functioning of adolescents if inadequately managed. Topical therapies remain the cornerstone of initial treatments due to their favorable safety profile and targeted action. This review summarizes evidence from randomized controlled trials, meta-analyses, and guidelines on key agents, including retinoids, benzoyl peroxide, topical antibiotics, and fixed-dose combinations. Topical therapies in acne offer effective management and reduce the chance of systemic antibiotic resistance.