Mechanochemical and Sonochemical Green Multicomponent Semisynthesis of Masticadienonic Acid Analogs

Isocyanide‐based multicomponent reactions (IMCRs) have emerged as efficient tools for the semisynthesis of natural product analogs, offering greener, faster, and more efficient compared to conventional multistep approaches. In this study, masticadienonic acid ( 5 ), a triterpenoid isolated from Pistacia mexicana , was employed in Passerini three‐component (P‐3CR) and Ugi four‐component (U‐4CR) reactions for accessing α‐acyloxycarboxamides ( 6a–e , 8a–c ) and bis ‐amides ( 14a–i ). Sonochemical (SC) and mechanochemical (MC) P‐3CR and U‐4CR green strategies were developed, contributing to the advancement of IMCR methodologies applied to synthesize natural product analogs within the framework of Green Chemistry.