Inflammatory Markers for Predicting Post-operative Acute Kidney Injury in Patients with Acute Type A Aortic Dissection

Abstract Background Acute kidney injury (AKI) is one of the most common peri-operative complications of acute aortic dissection. It contributes to in-hospital mortality and exerts adverse impacts on patients’ long-term survival. Objective To explore the predictive value of inflammatory markers for post-operative acute kidney injury in patients with acute type A aortic dissection. Methods Clinical data of 135 patients diagnosed with acute type A aortic dissection admitted to Anhui Provincial Chest Hospital from November 2022 to September 2025 were retrospectively analyzed. Patients were divided into the AKI group and non-AKI group. Logistic regression and receiver operating characteristic (ROC) curves were applied to evaluate the predictive performance of inflammatory markers for AKI. Results Among the 135 enrolled patients, 69 (51.1%) developed post-operative AKI. Compared with the non-AKI group, the AKI group presented significantly higher interleukin-6 (IL-6), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). Logistic regression showed that IL-6 (OR = 1.13, 95%CI: 1.01–1.04, P < 0.01), NLR (OR = 1.28, 95%CI: 1.13–1.47, P < 0.01) and PLR (OR = 1.02, 95%CI: 1.01–1.03, P = 0.013) were independent risk factors for AKI in patients with acute type A aortic dissection. ROC curve analysis demonstrated that NLR, PLR and IL-6 possessed favourable predictive accuracy. Conclusion IL-6, NLR and PLR are correlated with AKI occurrence in patients with acute type A aortic dissection and have good reference value for predicting post-operative AKI.