Direct C3-Cyanation of Indoles Enabled by Cyanobenziodoxolone (CBX) and HFIP
A direct C3-cyanation protocol for indole derivatives has been established using cyanobenziodoxolone (CBX) as the cyanating reagent and hexafluoroisopropanol (HFIP) as the solvent. This transformation proceeds efficiently under mild, catalyst-free, and inert-atmosphere-free conditions, providing a practical approach for the C3-cyanation of electronically favored indole substrates.
Authors
- Dan Xiao (ORCID: https://orcid.org/0009-0000-2347-0441)
- Yunfei Du (ORCID: https://orcid.org/0000-0002-0213-2854)
- Cong Li (ORCID: https://orcid.org/0000-0002-5316-5496)
- Yingjie Gao (ORCID: https://orcid.org/0009-0003-4037-4701)
- Xiangyu Zhan
- Zhijian Wang
Institutions
- Tianjin University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-11-09
- DOI
- https://doi.org/10.1021/acs.joc.6c00750
- Primary Topic
- Synthesis of Indole Derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00