Rare co occurrence of primary liver bile duct and gallbladder cancers

We present a case of concurrent hepatocellular carcinoma and gallbladder carcinoma, emphasizing the significance of considering multiple primary malignancies in the diagnostic evaluation of advanced or metastatic tumors. A male patient in his 70s presented with a one-day history of incidentally discovered liver mass, which was identified as an advanced stage hepatocellular carcinoma invading the gallbladder on imaging studies. The patient underwent successful targeted immunotherapy and hepatic arterial infusion chemotherapy (HAIC), followed by conversion therapy surgery.