Life as memory. Memory as life: hysteretic kinetics in the SABIO-RK database

Reconnaissance of the SABIO-RK kinetic database: 76,780 records, 100% coverage, zero corrupted lines. Three findings. (1) Hill coefficients: 2,826 records, median n = 1.5, 49.4% of values above 1.5 — equilibrium cooperativity is systematic in a static reference database. (2) Memory: 23 records in two publications with "hysteretic" in the title — human DHFR, 1989 (17 records) and rat pyruvate kinase, 1974 (6 records, up to 10 parameters including transition rate constants). The kinetic-law type "hysteretic" is absent from the schema; the term survives only in the bibliography. (3) Lag: zero records — the concept is absent from the lexicon entirely, even in the hysteretic works. Conclusion: measured non-equilibrium dynamics exist in the data, but the schema does not mark them. The hysteresis loop — the only loop that culture draws in full — is proposed as a common signature of two time scales in one carrier: proteins, viruses, humans. The full research log, including the dialogue protocol and illustrations, is published as supplementary material (Proza.ru, publication certificates No. 226110801428, No. 226110801460, No. 226110801495).

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-11-08
DOI
https://doi.org/10.5281/zenodo.24055592
Primary Topic
Gene Regulatory Network Analysis
Type
preprint
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preprint

Life as memory. Memory as life: hysteretic kinetics in the SABIO-RK database

Borodin Oleg BORODIN O.A.
Zenodo (CERN European Organization for Nuclear Research)
Gene Regulatory Network Analysis
preprint

Life as memory. Memory as life: hysteretic kinetics in the SABIO-RK database

Borodin Oleg BORODIN O.A.
preprint en

Abstract

Reconnaissance of the SABIO-RK kinetic database: 76,780 records, 100% coverage, zero corrupted lines. Three findings. (1) Hill coefficients: 2,826 records, median n = 1.5, 49.4% of values above 1.5 — equilibrium cooperativity is systematic in a static reference database. (2) Memory: 23 records in two publications with "hysteretic" in the title — human DHFR, 1989 (17 records) and rat pyruvate kinase, 1974 (6 records, up to 10 parameters including transition rate constants). The kinetic-law type "hysteretic" is absent from the schema; the term survives only in the bibliography. (3) Lag: zero records — the concept is absent from the lexicon entirely, even in the hysteretic works. Conclusion: measured non-equilibrium dynamics exist in the data, but the schema does not mark them. The hysteresis loop — the only loop that culture draws in full — is proposed as a common signature of two time scales in one carrier: proteins, viruses, humans. The full research log, including the dialogue protocol and illustrations, is published as supplementary material (Proza.ru, publication certificates No. 226110801428, No. 226110801460, No. 226110801495).

Zenodo (CERN European Organization for Nuclear Research)
Gene Regulatory Network Analysis
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